Agilent’s Crucial Challenge: A Stand for Its CRISPR Patents

Conal Cram
3 Min Read

Agilent Appeal: A Matter of Innovation and Patents

Agilent Appeal – In the rapidly advancing landscape of gene-editing technology, Agilent Technologies Inc., a notable figure in nucleic acid synthesis, has found itself in a significant dispute. The Silicon Valley-based company has announced its intent to appeal a recent reversal decision from the U.S. Patent and Trademarks Office (USPTO) concerning their innovative CRISPR guide RNA (gRNA) patents.

The Chemistry of Contention: Modified gRNA

The heart of this disagreement is rooted in Agilent’s work on chemically modified CRISPR gRNA. The patented approach—akin to enhancing a precision tool in genetic engineering—has resulted in a demonstrable improvement in the efficiency of CRISPR-based gene editing. The consequences of these chemical modifications on the gRNA:Cas enzyme complex were previously unknown, leaving a critical gap in the field that Agilent’s inventors have since filled.

Leaders in CRISPR Technologies

Agilent’s notable contributions to the field of gene editing are represented in its robust product lineup. Produced in their facilities in Santa Clara, California, and Boulder, Colorado, Agilent’s SureGuide research-grade and ClinGuide large-scale, cGMP-grade gRNA products offer the scientific community reliable tools for cutting-edge research and development.

The recent USPTO decision may have been a setback, but Agilent is not deterred. The company is preparing to appeal to the United States Court of Appeals for the Federal Circuit, signalling a commitment to stand behind the work of its scientific team. Agilent’s patents are set to hold strong through the entirety of the appeals process.


As Agilent gears up for this pivotal challenge, the firm remains dedicated to its role in gene editing advancements and continues to assert its leadership in guiding RNA production. The pending appeal carries significant implications for the wider biotech landscape and could influence the ongoing development and commercialization of CRISPR technologies.

This developing story underscores the complex world of biotechnological patents, illustrating the intricate dance between innovation and its legal protection. We will keep a close eye on the proceedings as they unfold, highlighting the impact of this crucial appeal on the future of gene-editing technology.

As we wrap up this insightful dive into Agilent’s CRISPR patent dispute, we invite you to share your thoughts and perspectives. What do you make of Agilent’s decision to appeal? How do you see this impacting the future of gene-editing technologies and the biotech industry as a whole?

Engage with us in the comments below. Whether you’re a biotech enthusiast, an industry professional, or just keen on understanding the unfolding drama in the world of genome editing, we’d love to hear your take on this story. Your insights could spark interesting discussions and deepen our understanding of this complex issue.

View our latest articles right here. Photo by Ousa Chea.

Share This Article
Conal is a seasoned tech industry professional and content writer for numerous tech publications. With a strong background in software engineering and digital media development, he's passionate about sharing the latest updates and insights in the tech industry, particularly in artificial intelligence and other disruptive trends. In his spare time he loves a mezze platter and a good film, and if he's not playing Fortnite or spending time with his daughter you can assume he's at the dry slopes!
Leave a comment

Leave a Reply

Your email address will not be published. Required fields are marked *